Biosciences and Biotechnology Division

Microbial Systems Biology Group

The Microbial Systems Biology Group probes basic biology and designs engineered microbial systems with applications in environmental biotechnology, biomanufacturing, and human health.

Using systems biology approaches, we uncover foundational mechanisms driving system level behavior and seek a predictive understanding of complex microbes and microbial communities. We harness this fundamental science to design systems at the protein, microbe, and community levels to confer biotechnological functions. We strive to develop basic knowledge and practical solutions to benefit national security.

Our research and capabilities

Our major research areas include:

Our capabilities include:

  • Multi-omic analyses (genomics, RNA-seq, proteomics, metabolite profiling) and bioinformatics
  • Advanced genetic engineering of model and non-model microbes
  • Enzyme engineering
  • Stable isotope probing
  • Advanced imaging, including cryoNanoSIMS and superresolution fluorescence microscopy
  • Microbiome and microbial consortia manipulation

Image shows a transmission electron micrograph of encapsulin nanocompartments. We study the mechanisms of encapsulin nanocompartment biosynthesis and regulation and engineer encapsulin systems to achieve new biosynthetic functions.

Transmission electron micrograph of encapsulin nanocompartments.

In the news

Our team

Yung, Mimi Cho
Stuart, Rhona Kayra
Brisson, Vanessa Lynn
Buss, Marjorie Theresa
Marjorie Buss
Gilbert, Naomi Elizabeth
Naomi Gilbert
Halvorsen, Tiffany Marie
Tiffany Halvorsen
Kimbrel, Jeff
Li, Wei
Mccall, Nathan Andrew
Nathan Mccall
Moreno, Marcus Vincent
Marcus Moreno
Rolison, Kristina Alyssa
Song, Fangchao
Fangchao Song
Wackelin, Daniel Joseph
Daniel Wackelin

Select publications