Lawrence Livermore National Laboratory



Peter Weber

Research Staff
Nuclear and Chemical Sciences Division


 +1 925-422-3018


DegreeDiscipline/InstitutionYear
Ph.D. Geography
University of California at Berkeley
2002
M.A. Geography
University of California at Berkeley
1997
B.S. Physics
Antioch College
1987

Research Interests

Mass spectrometry and microanalysis, secondary ion mass spectrometry, including applications to actinides and soft materials, elemental and isotopic tracers, nuclear forensics, microbial forensics, microbial ecology, salmon ecology and migration

Publications

K.E. Limburg, B.D Walther, Z. Lu, G. Jackman, J. Mohan, Y. Walther, A. Nissling, P.K. Weber, A.K Schmitt (in review) In search of the dead zone: use of otoliths for tracking fish exposure to hypoxia. Journal of Marine Systems.

X. Mayali, P.K. Weber, S. Mabery, J. Pett-Ridge (in review) Phylogenetic patterns in the microbial response to resource availability: amino acid incorporation in San Francisco Bay. PlosOne.

S. Ghosal, P.K. Weber, A. Laskin (in press) Spatially resolved chemical imaging of individual atmospheric particles using nano-scale imaging mass spectrometry: Insights into particle origin and chemistry. Analytical Methods.

J.Z., Lee, L.C. Burow, D. Woebken, M.D. Kubo, R, Craig Everroad, A. Spormann, P.K. Weber, J. Pett-Ridge, B.M. Bebout, T.M. Hoehler (in press) Fermentation couples Chloroflexi and sulfate-reducing bacteria to Cyanobacteria in hypersaline microbial mats. Frontiers in Microbiology.

L.C. Burow, D. Woebken, B. M. Bebout, I.P.G. Marshall, S.W. Singer, J. Pett-Ridge, L. Prufert-Bebout, A.M. Spormann, P. K. Weber and T.M. Hoehler (in press) Identification of Desulfobacterales as primary hydrogenotrophs in a complex microbial mat community. Geobiology.

K.J. Carpenter, P.K. Weber, J. Pett-Ridge, M.L. Davisson, M.I. Haverty, P.J. Keeling (2013) Correlated SEM, FIB-SEM, TEM, and NanoSIMS imaging of microbes from the hindgut of a lower termite: Methods for in-situ functional and ecological studies of uncultivable microbes. Microscopy and Microanalysis 19: 1490-1501.

J.F. Frisz, H.A. Klitzing, K. Lou, I.D. Hutcheon, P.K. Weber, J. Zimmerberg, M.L. Kraft (2013) Sphingolipid Domains in the Plasma Membranes of Fibroblasts are Not Enriched with Cholesterol. Journal of Biological Chemistry, 288:16855-16861.

J.F. Frisz, K. Lou, W.P. Hanafin, K.J. Carpenter, J. Zimmerberg, I.D. Hutcheon, P.K. Weber, M.L. Kraft (2013) High-resolution chemical imaging of sphingolipid distribution in the plasma membrane. PNAS USA 110:E613-22. www.pnas.org/cgi/doi/10.1073/pnas.1216585110

E.E. Nuccio, A. Hodge, J. Pett-Ridge, D.J. Herman, P.K. Weber, M.K. Firestone (2013) An arbuscular mycorrhizal fungus modifies the soil microbial community and nitrogen cycling during litter decomposition. Environmental Microbiology 15:1870-81.

X. Mayali, P.K. Weber, J. Pett-Ridge (2013) Estuarine bacterial taxa assimilate different ratios of nitrogen and carbon from amino acids. FEMS Microbiology Ecology. 83: 402-412. doi: 10.1111/j.1574-6941.12000.x

L.C. Burow, D. Woebken, I.P.G. Marshall, E.A. Lindquist, B.M. Bebout, L. Prufert-Bebout, T.M. Hoehler, S.G. Tringe, J. Pett-Ridge, P.K. Weber, A.M. Spormann, S.W. Singer. (2013) Anoxic carbon flux in photosynthetic microbial mats as revealed by metatranscriptomics and NanoSIMS. The ISME Journal 7(4):817-29. doi: 10.1038/ismej.2012.150.

L.E. Woodson, B.K. Wells, P.K. Weber, R.B. MacFarlane, G.E. Whitman, R.C. Johnson (2013) Size, growth, and origin-dependent mortality of juvenile Chinook salmon Oncorhynchus tshawytscha during early ocean residence. Marine Ecology Progress Series 487: 163-175.

M. Keiluweit, J.J. Bougoure, L.H. Zeglin, D.D. Myrold, P.K. Weber, M. Kleber, J. Pett-Ridge, and P.S. Nico (2012) Rapid Association of Microbial Amide N with Iron (hydr)oxides in a N-limited Forest Soil O-horizon. Geochimica et Cosmochimica Acta 95: 213-226.

D. Woebken, L. C. Burow, L. Prufert-Bebout, B. M. Bebout, T. M. Hoehler, J. Pett-Ridge, A. M. Spormann, P.K. Weber, S. W. Singer (2012) Identification of a novel cyanobacterial group as active diazotrophs in a coastal microbial mat using NanoSIMS analysis. The ISME Journal. doi: 10.1038/ismej.2011.200

X. Mayali, P.K. Weber, E.L. Brodie, S. Mabery, P.D. Hoeprich, and J. Pett-Ridge (2012) High-throughput isotopic analysis of RNA microarrays to quantify microbial resource use. The ISME Journal. doi: 10.1038/ismej.2011.175

R.C. Johnson, P.K. Weber, J.D. Wikert, M.L.Workman, R.B. MacFarlane, M.J. Grove, and A.K. Schmitt (2012) Managed metapopulations: Do salmon hatchery 'sources' lead to in-river 'sinks' in conservation? PLoS ONE 7(2): e28880. doi:10.1371/journal.pone.0028880.

R.L. Wilson, J.F. Frisz, W.P. Hanafin, K.J. Carpenter, I.D. Hutcheon, P.K. Weber, and M.L. Kraft (2012) Fluorinated colloidal gold immunolabels for imaging select proteins in parallel with lipids using high-resolution secondary ion mass spectrometry. Bioconjugate Chemistry 23:450–460 DOI: 10.1021/bc200482z

L.C. Burow, D. Woebken, B.M. Bebout, P.J. McMurdie, S. W. Singer, J. Pett-Ridge, L. Prufert-Bebout, A.M. Spormann, P.K. Weber and T.M. Hoehler (2011) Hydrogen production in photosynthetic microbial mats in the Elkhorn Slough Estuary, Monterey Bay. The ISME Journal. doi: 10.1038/ismej.2011.142

B. Jacobsen, J. Matzel, I.D. Hutcheon, A.N. Krot, K. Nagashima, H.A. Ishii, E. Ramon, P.K. Weber, B.S. Meyer, A.M. Davis, F.J. Ciesla, Q.-Z. Yin (2011) Formation of short-lived radionuclides during epoch of late-stage irradiation in the protoplanetary disk. The Astrophysical Journal Letters 731:L28. doi: 10.1088/2041-8205/731/2/L28

J.I. Simon, I.D. Hutcheon, S.B. Simon, J.E.P. Matzel, E.C. Ramon, P.K. Weber, L. Grossman, and D.J. DePaolo (2011) Oxygen isotope variations at the margin of a CAI records circulation within the solar nebula. Science 331:1175-1178 DOI: 10.1126/science.1197970

F. Wolfe-Simon, J. Switzer Blum, T.R. Kulp, G.W. Gordon, S.E. Hoeft, J. Pett-Ridge, J.F. Stolz, S.M. Webb, P.K. Weber, P.C.W. Davies, A.D. Anbar, and R.S. Oremland (2011) Response to comments on "A bacterium that can grow by using arsenic instead of phosphorus." Science 332: 1149.

F. Wolfe-Simon, J. Switzer Blum, T.R. Kulp, G.W. Gordon, S.E. Hoeft, J. Pett-Ridge, J.F. Stolz, S.M. Webb, P.K. Weber, P.C.W. Davies, A.D. Anbar, and R.S. Oremland (2011) A bacterium that can grow by using arsenic instead of phosphorus. Science 332: 1163-1166. doi: 10.1126/science.1197258

C.C. Phillis, D.J. Ostrach, B.L. Ingram, and P.K. Weber (2011) Evaluating otolith Sr/Ca as a tool for reconstructing estuarine habitat use. Canadian Journal of Fisheries and Aquatic Sciences 68: 360–373. LLNL-JRNL-463245; doi: 10.1139/F10-152

C.R. Anderton, K. Lou, P.K. Weber, I.D. Hutcheon, and M.L. Kraft (2011) Correlated AFM and NanoSIMS imaging to probe cholesterol-induced changes in phase behavior and non-ideal mixing in ternary lipid membranes. Biochimica et Biophysica Acta-Biomembranes 1808: 307-315. LLNL-JRNL-463216; doi: 10.1016/j.bbamem.2010.09.016

J.E.P. Matzel, H.A. Ishii, D. Joswiak, I.D. Hutcheon, J.P. Bradley, D. Brownlee, P.K. Weber, N. Teslich, G. Matrajt, K.D. McKeegan, and G.J. MacPherson (2010) Constraints on the formation age of cometary material from the NASA stardust mission. Science 328: 483-486.

Ghosal, S., T.J. Leighton, K.E. Wheeler, I. D. Hutcheon, and P. K. Weber (2010) Spatially resolved characterization of water and ion incorporation in Bacillus spores, Applied and Environmental Microbiology 76: 3275–3282.

P.K. Weber, G.A. Graham, N.E. Teslich, W. MoberlyChan, S. Ghosal, T.J. Leighton, K.E. Wheeler (2010) NanoSIMS imaging of Bacillus spores sectioned by Focused Ion Beam. Journal of Microscopy 238: 189-199.

L.F. Dobrzhinetskaya, R. Wirth, J. Yang, I.D. Hutcheon, P.K. Weber, H.W. Green, II (2009) High pressure highly reduced nitrides and oxides from chromite of a Tibetan ophiolite. Proceedings of the National Academy of Science, USA 106: 19233–19238.

X. Wang, X. Li, L. Zhang, Y. Yoon, P.K. Weber, H. Wang, J. Guo, and H. Dai (2009) N-doping of graphene through electro-thermal reactions with ammonia. Science 324:768-771.

J.A. Finzi, J. Pett-Ridge, P.K. Weber, R. Popa, S.J. Fallon, T. Gunderson, I.D. Hutcheon, K.H. Nealson, D.G. Capone (2009) Fixation and fate of carbon and nitrogen in Trichodesmium IMS101 using nanometer resolution secondary ion mass spectrometry (NanoSIMS). Proceedings of the National Academy of Science, USA 106: 6345-6350.

S. Ghosal, S.J. Fallon, T.J. Leighton, K.D. Wheeler, M.J. Kristo, I.D. Hutcheon, and P.K. Weber (2008) Analysis of bacterial spores using Nano-Secondary Ion Mass Spectrometry (NanoSIMS). Analytical Chemistry 80: 5986-5992.

G.A. Graham, N.E. Teslich, A.T. Kearsley, F.J. Stadermann, R.M. Stroud, Z. Dai, H.A. Ishii, I.D. Hutcheon, S.A. Bajt, C.J. Snead, P.K. Weber, J.P. Bradley (2008) Applied focused ion beam techniques to the sample preparation of astromaterials for integrated nanoanalysis. Meteoritics & Planetary Science 43:561-569.

S. Behrens, T. Lösekann, J. Pett-Ridge, P.K. Weber, W.-O. Ng, B. S. Stevenson, I.D. Hutcheon, D.A. Relman, and A.M. Spormann (2008) Linking microbial phylogeny to metabolic activity at the single cell level using enhanced element labeling - catalyzed reporter deposition fluorescence in situ hybridization (EL-FISH) and NanoSIMS. Applied and Environmental Microbiology 74: 3143-3150.

A.-L. Auzende, J. Badro, F. Ryerson, P.K. Weber, S.J. Fallon, A. Addad, J. Sieber, G. Fiquet (2008) Element partitioning between magnesium silicate perovskite and ferropericlase: new insights into bulk lower-mantle geochemistry. Earth and Planetary Science Letters 269: 164-174.

J. Badro, F. Ryerson, P.K. Weber, A. Ricolleau, S.J. Fallon, I.D. Hutcheon, F. Albarède (2007) Chemical imaging with NanoSIMS: A window into deep-Earth geochemical processes. Earth and Planetary Science Letters 262: 543-551.

J.W. Moreau, P.K. Weber, M.C. Martin, B. Gilbert, I.D Hutcheon and J.F. Banfield (2007) Extracellular proteins limit the dispersal of biogenic nanoparticles. Science 316: 1600-1603.

R. Popa, P.K. Weber, J. Pett-Ridge, J.A. Finzi, S.J. Fallon, I.D. Hutcheon, K.H. Nealson and D.G. Capone (2007) Carbon and nitrogen fixation and metabolite exchange in and between individual cells of Anabaena oscillarioides. The International Society of Microbial Ecology Journal 1: 354-360.

M.L. Kraft, P.K. Weber, M.L. Longo, I.D. Hutcheon and S.G. Boxer (2006) Phase separation of lipid membranes analyzed with high-resolution secondary-ion mass spectrometry. Science 313(5795): 1948-1951.

S.B. Simon, L. Grossman, I.D. Hutcheon, D.L. Phinney, P.K. Weber and S.J. Fallon (2006) Formation of spinel-, hibonite-rich inclusions found in CM2 carbonaceous chondrites. American Mineralogist 91(10):1675-1687.

M.L. Kraft, S.F. Fishel, C. Galli Marxer, P.K. Weber, I.D. Hutcheon and S.G. Boxer (2006) Quantitative analysis of supported membrane composition using the NanoSIMS. Applied Surface Science 252: 6950-6956.

C.T. Solomon, P.K. Weber, J.J. Cech, B.L. Ingram, M.E. Conrad, M.V. Machavaram, A.R. Pogodina, and R.L. Franklin (2006) Experimental determination of the sources of carbon to fish otoliths, for application of stable isotope techniques to otolith chronosequences. Canadian Journal of Fisheries and Aquatic Sciences 63: 79-89.

P.K. Weber, C.R. Bacon, I.D. Hutcheon, B.L. Ingram, and J.L. Wooden (2005) Ion microprobe measurement of strontium isotopes in calcium carbonate. Geochimica et Cosmochimica Acta 69(5): 1225-1239.

C. Galli Marxer, M.L. Kraft, P.K. Weber, I.D. Hutcheon, and S.G. Boxer (2005) Supported membrane composition analysis by secondary ion mass spectrometry with high lateral resolution, Biophysical Journal 88: 2965-2975.

J.P. Bradley, Z.R. Dai, R. Erni, N.D. Browning, G.A. Graham, P.K. Weber, J.B. Smith, I.D. Hutcheon, H. Ishii, S. Bajt, C. Floss, F.J. Stadermann, and S. Sandford (2005) An astronomical 2175 Å feature in interplanetary dust particles. Science 307: 244-247.

C.R. Bacon, P.K. Weber, K.A. Larson, R. Reisenbichler, J.A. Fitzpatrick, and J.L. Wooden (2004) Ion microprobe Sr isotope and Sr/Ca analyses of otoliths reveal migration and rearing histories of chinook salmon (Oncorhynchus tshawytscha). Canadian Journal of Fisheries and Aquatic Sciences 61: 2425-2439.

M. Wainwright, P.K. Weber, J.B. Smith, I.D. Hutcheon, B. Klyce, N.C. Wickramasinghe, J.V. Narlikar, and P. Rajaratnam (2004) Studies on bacteria-like particles sampled from the stratosphere. Aeorobiologia 20: 237-240.

P.K. Weber, I.D. Hutcheon, K.D. McKeegan, and B.L. Ingram (2002) Otolith sulfur isotope method to reconstruct salmon (Oncorhynchus tshawytscha) life history. Canadian Journal of Fisheries and Aquatic Sciences 59: 587-591.

B.L. Ingram and P.K. Weber (1999) Salmon origin in California's Sacramento-San Joaquin river system as determined by otolith strontium isotope compositions. Geology 27: 851-854.

Chapters and Reviews:

C.W. Mueller, P.K. Weber, M.R. Kilburn, C. Hoeschen, M. Kleber and J. Pett-Ridge (in press) Advances in the Analysis of Biogeochemical Interfaces: NanoSIMS to Investigate Soil Microenvironments. Advances in Agronomy, 121: xx-xx.

H. Klitzing, P.K. Weber, M.L. Kraft (2013) Secondary Ion Mass Spectrometry Imaging of Biological Membranes at High Spatial Resolution. In A.A. Sousa & M.J. Kruhlak, Eds., Nanoimaging: Methods and Protocols, Methods in Molecular Biology 950, Springer Protocols, Humana Press, New York.

J. Pett-Ridge & P.K. Weber (2012) NanoSIP: NanoSIMS Applications for Microbiology. In A. Navid, Ed., Microbial Systems Biology: Methods and Protocols, Methods in Molecular Biology 881, Springer Protocols, Humana Press, New York, pp. 375-408. ISBN 978-1-61779-826-9 ; LLNL-BOOK-483216

S.G. Boxer, M.L. Kraft, and P.K. Weber (2009) Advances in imaging secondary ion mass spectrometry for biological samples. Annual Review of Biophysics 38: 53-74.

Patents and Record of Inventions:

J. Pett-Ridge, P. Hoeprich, P.K. Weber, E. Brodie (2009) CHIP-SIP: Quantification of nucleic acid stable isotope labeling with biopolymer microarrays and secondary ionization mass spectrometry.

Invited Presentations:

P.K. Weber, M.L. Davisson, S.P. Velsko, Validation of quantitative elemental analysis of bulk and trace samples, American Vacuum Society, Long Beach, CA, October 29, 2013.

P.K. Weber, S.D. Gates, R.C. Condit, N. Moussatche, and A.J. Malkin, AFM and NanoSIMS analysis of Vaccinia virions, Microscopy and Microanalysis, August 6, 2013. LLNL-PRES-641936

P.K. Weber, Geological and geobiology applications of NanoSIMS, Department Seminar, Department of Geological and Environmental Sciences, Stanford University, Stanford, CA, February 26, 2013.

P.K. Weber, Translating high resolution chemical imaging to medical applications, Oregon Health Sciences University, Portland, OR, December 22, 2011.

P.K. Weber, Ecological applications of secondary ion mass spectrometry, UCLA NSF SIMS Workshop, Los Angeles, CA, February 25, 2011.

P.K. Weber, S.P. Velsko, M.L. Davisson, Validation of sample matching by quantitative elemental analysis using trace and bulk samples, Department of Homeland Security Science and Technology Division Bioforensics R&D Program Review, Arlington, VA, August 20, 2010

P.K. Weber, M.L. Davisson, S.P. Velsko, Quantitative elemental analysis, Department of Homeland Security Science and Technology Division 2010 Annual Chemical and Biological Division Performers Conference, Arlington, VA, August 17, 2010.

P.K. Weber, M.L. Kraft, J. Frisz, K. Carpenter, I.D. Hutcheon, Chemical Imaging of the Cell Membrane by NanoSIMS, Microscopy and Microanalysis 2010, Portland, OR, August 7, 2010.

P.K. Weber, Chemical imaging of biological samples by NanoSIMS, Gray Research Group, Lawrence Berkeley National Laboratory, October 29, 2009.

P.K. Weber, B. Viani, M.L. Davisson, S.P. Velsko, Nanometer-scale secondary ion mass spectrometry for microbial characterization, National Research Council Committee on Review of the Scientific Approaches used during the FBI's Investigation of the 2001 Bacillus anthracis Mailings, September 25, 2009

P.K. Weber, Membranes to Microbes: High Resolution Chemical Imaging of Biological Samples, USDA-ARS Western Regional Research Center, Albany, CA, March 24, 2009.

P.K. Weber, Subcellular chemical imaging by NanoSIMS, 12th International Symposium on Microbial Ecology, Cairns, Australia, August 22, 2008

P.K. Weber, Microbial Ecology: How to tell who does what by NanoSIMS, 4th Biennial Geological SIMS Workshop, University of Wisconsin, Madison, WI, June 14, 2008.

P.K. Weber, Membranes to Meteorites: High resolution chemical imaging by NanoSIMS, Geology Department Seminar, Portland State University, November 9, 2007.

P.K. Weber, Material science applications of NanoSIMS, Material Science Institute Workshop, University of Oregon, November 8, 2007.

P.K. Weber, Cell Membranes and Microbes: High resolution biological imaging by NanoSIMS, Institute of Molecular Biology Seminar, University of Oregon, November 7, 2007

P.K. Weber, Geological applications of NanoSIMS, Department of Geological Sciences Seminar, University of Oregon, November 7, 2007.

P.K. Weber, Cyanobacteria and Cell Membranes: Two examples of high resolution biological imaging by NanoSIMS, Lockheed Martin Advanced Technology Center Colloquium, Palo Alto, CA, November 1, 2007.

P.K. Weber, S. Ghosal, S.J. Fallon, I.D. Hutcheon, T.J. Leighton, K.D. Wheeler. Chemical characterization of bacterial spores by NanoSIMS, ASCO Microbial Bioforensics Workshop, Defense Threat Reduction Agency, Ft. Belvoir, VA, June 21, 2006

P.K. Weber, S.J. Fallon, J. Pett-Ridge, S. Ghosal, and I.D. Hutcheon, Chemical imaging of biological materials by NanoSIMS using isotopic and elemental labels, 19th Annual SIMS Workshop, Rancho Mirage, CA May 19, 2006.

P.K. Weber, S.J. Fallon, J. Pett-Ridge, S. Ghosal, and I.D. Hutcheon, High spatial resolution isotopic measurements by NanoSIMS, Isotope Geology Seminar (Donald DePaolo), Earth and Planetary Science, University of California, Berkeley, CA, April 26, 2006.

P.K. Weber, S.J. Fallon, J. Pett-Ridge, S. Ghosal, C.E. Ramon and I.D. Hutcheon, High resolution imaging of microbial systems by NanoSIMS, Geomicrobiology Group (Prof. Jill Banfield), Earth and Planetary Science, University of California, Berkeley, CA, December 17, 2005.

P.K. Weber, S.J. Fallon, J. Pett-Ridge, S. Ghosal, C.E. Ramon and I.D. Hutcheon, High resolution trace element and isotopic imaging of microbial systems by NanoSIMS, American Geophysical Union Fall Meeting, San Francisco, CA, December 5-9, 2005.

P.K. Weber, J.C. Finlay, M.E. Power, C.C. Phillis, C.E. Ramon, G.F. Eaton and B.L. Ingram, Fish Movement and Dietary History Derived from Otolith δ13C, American Geophysical Union Fall Meeting, San Francisco, CA, December 5-9, 2005.

P.K. Weber, J.B. Smith and I.D Hutcheon, Chemical imaging of biological materials by NanoSIMS, 31st FACSS Meeting, Portland, OR, October 3-7, 2004.


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