Lawrence Livermore National Laboratory



Carlos Valdez

Research Staff
Nuclear and Chemical Sciences Division


 +1 925-423-1804


DegreeDiscipline/InstitutionYear
Postdoctoral Research Associate Chemistry
The Scripps Research Institute
2008
Ph.D. Chemistry
University of California at Berkeley
2006
B.S. Chemistry
Florida International University
2000

Research Interests

My current interest lies in the field of chemical warfare agents and broadly covers methods for their analysis (GC-MS, LC-MS, and NMR Spectroscopy), destruction using novel, regiospecific catalytic processes, and the development of medical countermeasures against them.

Honors and Awards

  • LLNL Excellence in Publication Award in the Applied Sciences (2016).
  • LLNL S Program Tech Base Grant Award (2016).
  • LLNL Excellence in Publication Award (2015).
  • LLNL Director’s Institutional Operational Excellence Award (2013).
  • LLNL Directorate Gold Award (2013).
  • LLNL Spot Award (2012).
  • National Physical Science Consortium Graduate Fellowship (2001–2006).
  • University of California, Berkeley, College of Chemistry Grant Award (2002–2006).
  • Cancer Research Training Award, National Cancer Institute (2000).

Recent Publications

40. Mayer, B. P.*; Valdez, C. A.; DeHope, A. J.; Spackman, P. E.; Williams. A. M. “Statistical Analysis of the Chemical Attribution Signatures of 3-Methylfentanyl and its Methods of Production” Talanta 186, 645–654 (2018) [DOI]

39.  Williams, A. M.*; Vu, A. K.; Jansson, D.; Mayer, B. P.; Hok, S.; Norlin, R.; Valdez, C. A.; Nilsson, C.; Åstot, C.; Alcaraz, A. “Extraction and Detection of Russian VX and its Chemical Attribution Signatures in Food and Environmental Matrices at LLNL” Talanta 186, 607–614 (2018) [DOI]

38. Jansson, D.*; Wiklund Lindström, S.; Norlin, R.; Hok, S.; Valdez, C. A.; Williams, A. M.; Alcaraz, A.; Nilsson, C.; Åstot, C. “Part 2: Forensic attribution profiling of Russian VX in food using Liquid Chromatography-Mass Spectrometry” Talanta 186, 597–606 (2018) [DOI]

37. Höjer Holmgren, K.; Valdez, C. A.; Magnusson, R.; Vu, A. K.; Lindberg, S.; Williams, A. M.; Alcaraz, A.; Åstot, C.; Hok, S.*; Norlin, R.* “Part 1: Tracing Russian VX to its synthetic routes by multivariate statistics of chemical attribution signatures” Talanta 186, 586-596 (2018) [DOI]

36. Valdez, C. A.*, Marchioretto, M. K.; Leif, R. N.; Hok, S. “Efficient derivatization of methylphosphonic and aminoethylsulfonic acids related to nerve agents simultaneously via methylation employing trimethyloxonium tetrafluoroborate for their detection and identification in soils by EI-GC-MS and GC-FPD” Forensic Sci. Int. 288, 159–168 (2018) [DOI]

35. Valdez, C. A.*, Leif, R. N., Hok, S., Alcaraz, A. “Assessing the reliability of the NIST library during routine GC-MS analyses: Structure and spectral data corroboration for 5,5-diphenyl-1,3-dioxolan-4-one during a recent OPCW proficiency test” J. Mass Spectrom. 53, 419–422 (2018) [DOI]

34. Valdez, C. A.*; Leif, R. N.; Hok, S.; Hart, B. R. “Analysis of Chemical Warfare Agents by Gas Chromatography-Mass Spectrometry: Methods for their Direct Detection and Derivatization Approaches for the Analysis of their Degradation Products” Rev. Anal. Chem. 37(1), 1–26 (2018) [DOI] Article highlighted in Science Discoveries [DOI]

33.  Kennedy, D. J.; Leif, R. N.; Mayer, B. P.; Valdez, C. A.* “Kinetic Studies on the Green and Practical Iodide-mediated Dealkylation of Tributylphosphate (TBP) using Nuclear Magnetic Resonance Spectroscopy” Anal. Chem. Lett. 7, 470–478 (2017) [DOI]

32. Malfatti, M. A.*; Enright, H. A.; Be, N. A.; Kuhn, E. A.; Hok, S.; Windy McNerney, M.; Lao, V.; Nguyen, T. H.; Lightstone, F. C.; Carpenter, T. S.; Bennion, B. J.; Valdez, C. A. The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs” Chem. Biol. Interact. 277, 159–167 (2017) [DOI]. Our work on oximes highlighted in Science magazine [DOI]

31. Bennion, B. J.; Be, N. A.; McNerney, M. W.; Lao, V.; Carlson, E. M.; Valdez, C. A.; Malfatti, M. A.; Enright, H. A.; Nguyen, T. H.; Lightstone, F. C.; Carpenter, T. S.* “Predicting a Drug’s Membrane Permeability: Evolution of a Computational Model Validated With In Vitro Permeability Assay Data” J. Phys. Chem. B 121, 5228–5237 (2017) [DOI]

30. Valdez, C. A.*; Leif, R. N. “Simultaneous and Practical Difluoromethylation of Triclosan, 2,4,6-Trichlorophenol and Pentachlorophenol in Soils for their Qualitative Detection by Electron Ionization GC-MS” Anal. Chem. Lett. 7, 11–19 (2017) [DOI]

29. Valdez, C. A.*; Leif, R. N.; Alcaraz, A. “Effective methylation and identification of phosphonic acids relevant to chemical warfare agents mediated by trimethyloxonium tetrafluoroborate for their qualitative detection by gas chromatography-mass spectrometry” Anal. Chim. Acta 933, 134–143 (2016) [DOI]

28. Mayer, B. P.; Lau, E. Y.; Kennedy, D. J.; Valdez, C. A.* “Solution-State Structure and Affinities of Cyclodextrin:Fentanyl Complexes by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation” J. Phys. Chem. B 120, 2423–2433 (2016) [DOI]

27. Valdez, C. A. “Total synthesis of Tetrodotoxin: A historical account.”  Book Chapter in Studies in Natural Products Chemistry. Atta-ur Rahman, Ed.; Elsevier, Amsterdam: Netherlands, 47, 235–260 (2016) [DOI]

26. Kennedy, D. J.; Mayer, B. P.; Baker, S. E.; Valdez, C. A.* “Kinetics and speciation of paraoxon hydrolysis by Zn(II)-azamacrocycle catalysts” Inorg. Chim. Acta 436, 123–131 (2015) [DOI]

25. Valdez, C. A.*; Leif, R. N. “Chemical tagging of chlorinated phenols for their facile detection and analysis by NMR spectroscopy” Anal. Bioanal. Chem. 407, 3539–3543 (2015) [DOI]

24. Vericella, J. J.; Baker, S. E.; Stolaroff, J. K.; Duoss, E. B.; Hardin IV, J. O.; Lewicki, J.; Glogowski, E.; Floyd, W. C.; Valdez, C. A.; Smith, W. L.; Satcher Jr., J. H.; Bourcier, W. L.; Spadaccini, C. M.*; Lewis, J. A.*; Aines, R. D.* “Encapsulated liquid sorbents for carbon dioxide capture” Nat. Commun. 6, 6124 (2015) [DOI]

23. Valdez, C. A.; Leif, R. N.; Mayer, B. P.* “An efficient, optimized synthesis of fentanyl and related analogs” PLoS One 9, e108250 (2014) [DOI]

22. Valdez, C. A.*; Leif, R. N.; Hart, B. R. “Rapid silylation of ß-amino alcohols at room temperature mediated by N-methylimidazole for enhanced detectability by gas chromatography/electron ionization mass spectrometry” Rapid Commun. Mass Spectrom. 28, 2217–2221 (2014) [DOI]

21. Kulik, H. J.; Wong, S. E.; Baker, S. E.; Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.*; Lightstone, F. C.* “Developing an approach for first-principles catalyst design using structural databases: application to carbon capture” Acta Crystallogr. C Struct. Chem. 70, 123–131 (2014) [DOI]

20. Albo, R. L. F.; Valdez, C. A.*; Leif, R. N.; Mulcahy, H. A.; Koester, C. “An alternate, highly efficient derivatization of pinacolyl alcohol for enhanced detection in gas chromatography-mass spectrometry using electron impact ionization” Anal. Bioanal. Chem. 406, 5231–5234 (2014) [DOI]

Patents

13. Valdez, C. A.; Vu, A. K. “Methods for the selective detection of alkyne-presenting molecules and related compositions and systems” 9791463 (2017).

12. Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” 9453028 (2016).

11. Floyd III, W. C.; Valdez, C. A.; Aines, R. D.; Baker, S. E.; Satcher Jr., J. H. “Acyclic aza-containing ligands for use as catalytic carbon capture systems” 9259725 (2016).

10. Singh, R.; Li, H.; Zhao, H.; Kolluri, R.; Tso, K.; Ramphal, J.; Gu, S.; Valdez, C.; Zhang, J.; Stauffer, E.; Duncton, M.; Alvarez, S. “Protein kinase C inhibitors and uses thereof” 9149475 (2015).

9. Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” 9095593 (2015).

8. Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” 9040527 (2015).

7. Han, T. Y-j.; Valdez, C. A.; Olson, T. Y.; Kim, S. H.; Satcher Jr., J. H. “Rapid detection and identification of energetic materials with surface enhanced Raman spectroscopy (SERS)” 9012241 (2015).

6. Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.; Wong, S. E.; Baker, S. E.; Lightstone, F. C.; Stolaroff, J. K. “Tethered catalysts for the hydration of carbon dioxide” 8877069 (2014).

5. Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” 8519837 (2013).

4. Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.; Baker, S. E. “Synthesis of triazole-based and imidazole-based zinc catalysts” 8394351 (2013).

3. Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” 8394951 (2013).

2. Singh, R.; Li, H.; Zhao, H.; Kolluri, R.; Tso, K.; Ramphal, J.; Gu, S.; Valdez, C.; Zhang, J.; Stauffer, E.; Duncton, M.; Alvarez, S. “Protein kinase C inhibitors and uses thereof” 8377924 (2013).

1. Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” 8278299 (2012).

Technical Reports

11. Singleton, M. J.; Valdez, C. A.; Hok, S.; Mulcahy, H. A. “Compound Specific Stable Isotope Signatures of Chemical Threat Agents: Incapacitants and Agents: Year 1 Final Report” 2016, LLNL-TR-704350.

10. Mayer, B. P.; Valdez, C. A.; DeHope, A. J.; Spackman, P. E.; Sanner, R. D.; Martinez, H. P.; Williams, A. M. “Multivariate Statistical Analysis of Orthogonal Mass Spectral Data for the Identification of Chemical Attribution Signatures of 3-Methylfentanyl” 2016, LLNL-TR-703546.

9. Mayer, B. P.; Corzett, T.; Corzett, M.; Valdez, C. A.; Harding, R.; Hok, S.; Kennedy, D. J.; Williams, A. M. “Towards the Application of Multinuclear NMR for the Detection of the Adduction of Cholinesterases by Sarin and the Kinetics of the Subsequent Aging Process” 2015, LLNL-TR-668860.

8. Williams, A. M.; Valdez, C. A.; Hok, S.; Udey, R. N.; Vu, A. K. “Synthesis of GB- and VX-Adducted Nonapeptides and HD-Adducted Tripeptides Indicative of Butyrylcholinesterase Exposure to GB and VX or Albumin Exposure to HD” 2013, LLNL-TR-646332.

7. Hok, S.; Udey, R.; Vu, A. K.; Valdez, C. A. “Expanded Pathway Signatures Analysis” DHS Chemical Forensics and Attribution Program, 2013.

6. Hok, S.; Valdez, C. A. “Pathway Signatures Analysis” DHS Chemical Forensics and Attribution Program, 2012.

5. Hok, S.; Valdez, C. A.; Koester, C. “Lewisite I Synthesis.” 2012, LLNL-TR-599032.

4. Williams, A. M.; Mulcahy, H. A.; Leif, R. N.; Valdez, C. A.; Vu, A. K. “Extraction and Detection of US VX and its Chemical Attribution Signatures in Food Matrices” 2012, LLNL-TR-598692.

3. Williams, A. M.; Mulcahy, H. A.; Leif, R. N.; Valdez, C. A.; Vu, A. K. “Preliminary Report on the Extraction and Detection of US VX and its Chemical Attribution Signatures in Bottled Water” 2012, LLNL-TR-584672.

2. Martin, A. N.; Valdez, C. A.; Moulik, A.; Alcaraz, A. “Analysis of brodifacoum synthetic pathways for forensic applications” 2010, LLNL-TR-433953.

1. Hok, S.; Valdez, C. A. “Pathway Signatures Analysis” DHS Chemical Forensics and Attribution Program, 2010.


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