Lawrence Livermore National Laboratory



Carlos Valdez

Research Staff
Nuclear and Chemical Sciences Division


 +1 925-423-1804


DegreeDiscipline/InstitutionYear
Postdoctoral Research Associate Chemistry
The Scripps Research Institute
2008
Ph.D. Chemistry
University of California at Berkeley
2006
B.S. Chemistry
Florida International University
2000

Research Interests

  • Organometallic chemistry
  • Carbohydrate chemistry
  • Heterocyclic chemistry
  • Forensic chemistry

Honors and Awards

  • LLNL Excellence in Publication Award in the Applied Sciences (2016).
  • LLNL S Program Tech Base Grant Award (2016).
  • LLNL Excellence in Publication Award (2015).
  • LLNL Director's Institutional Operational Excellence Award (2013)
  • LLNL Directorate Gold Award (2013).
  • LLNL Spot Award (2012).
  • National Physical Science Consortium Graduate Fellowship (2001-2006).
  • University of California, Berkeley, College of Chemistry Grant Award (2002-2006).
  • Cancer Research Training Award, National Cancer Institute (2000).

Recent Publications

Kennedy, D. J.; Leif, R. N.; Mayer, B. P.; Valdez, C. A.* “Kinetic Studies on the Green and Practical Iodide-mediated Dealkylation of Tributylphosphate (TBP) using Nuclear Magnetic Resonance Spectroscopy” Accepted in Anal. Chem. Lett.

Valdez, C. A.*; Leif, R. N.; Hok, S.; Hart, B. R. “Analysis of Chemical Warfare Agents by Gas Chromatography-Mass Spectrometry: Methods for their Direct Detection and Derivatization Approaches for the Analysis of their Degradation Products” Rev. Anal. Chem. ASAP [DOI]

Malfatti, M. A.*; Enright, H. A.; Be, N. A.; Kuhn, E. A.; Hok, S.; Windy McNerney, M.; Lao, V.; Nguyen, T. H.; Lightstone, F. C.; Carpenter, T. S.; Bennion, B. J.; Valdez, C. A. The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs” Chem. Biol. Interact. 277, 159-167 (2017) [DOI]

Bennion, B. J.; Be, N. A.; McNerney, M. W.; Lao, V.; Carlson, E. M.; Valdez, C. A.; Malfatti, M. A.; Enright, H. A.; Nguyen, T. H.; Lightstone, F. C.; Carpenter, T. S.* “Predicting a Drug’s Membrane Permeability: Evolution of a Computational Model Validated With In Vitro Permeability Assay Data” J. Phys. Chem. B 121, 5228-5237 (2017) [DOI]

Valdez, C. A.*; Leif, R. N. “Simultaneous and Practical Difluoromethylation of Triclosan, 2,4,6-Trichlorophenol and Pentachlorophenol in Soils for their Qualitative Detection by Electron Ionization GC-MS” Anal. Chem. Lett. 7, 11-19 (2017) [DOI]

Valdez, C. A.*; Leif, R. N.; Alcaraz, A. “Effective methylation and identification of phosphonic acids relevant to chemical warfare agents mediated by trimethyloxonium tetrafluoroborate for their qualitative detection by gas chromatography-mass spectrometry” Anal. Chim. Acta 933, 134-143 (2016) [DOI]

Mayer, B. P.; Lau, E. Y.; Kennedy, D. J.; Valdez, C. A.* “Solution-State Structure and Affinities of Cyclodextrin:Fentanyl Complexes by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation” J. Phys. Chem. B 120, 2423-2433 (2016) ) [DOI]

Valdez, C. A. “Total synthesis of Tetrodotoxin: A historical account.” Book Chapter in Studies in Natural Products Chemistry. Atta-ur Rahman, Ed.; Elsevier, Amsterdam: Netherlands, 47, 235-260 (2016) [DOI]

Kennedy, D. J.; Mayer, B. P.; Baker, S. E.; Valdez, C. A.* “Kinetics and speciation of paraoxon hydrolysis by Zn(II)-azamacrocycle catalysts” Inorg. Chim. Acta 436, 123-131 (2015) [DOI]

Valdez, C. A.*; Leif, R. N. “Chemical tagging of chlorinated phenols for their facile detection and analysis by NMR spectroscopy” Anal. Bioanal. Chem. 407, 3539-3543 (2015) [DOI]

Vericella, J. J.; Baker, S. E.; Stolaroff, J. K.; Duoss, E. B.; Hardin IV, J. O.; Lewicki, J.; Glogowski, E.; Floyd, W. C.; Valdez, C. A.; Smith, W. L.; Satcher Jr., J. H.; Bourcier, W. L.; Spadaccini, C. M.*; Lewis, J. A.*; Aines, R. D.* “Encapsulated liquid sorbents for carbon dioxide capture” Nat. Commun. 6, 6124 (2015) [DOI]

Valdez, C. A.; Leif, R. N.; Mayer, B. P.* “An efficient, optimized synthesis of fentanyl and related analogs” PLoS One 9, e108250 (2014) [DOI]

Valdez, C. A.*; Leif, R. N.; Hart, B. R. “Rapid silylation of ß-amino alcohols at room temperature mediated by N-methylimidazole for enhanced detectability by gas chromatography/electron ionization mass spectrometry” Rapid Commun. Mass Spectrom. 28, 2217-2221 (2014) [DOI]

Kulik, H. J.; Wong, S. E.; Baker, S. E.; Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.*; Lightstone, F. C.* “Developing an approach for first-principles catalyst design using structural databases: application to carbon capture” Acta Crystallogr. C Struct. Chem. 70, 123-131 (2014) [DOI 

Albo, R. L. F.; Valdez, C. A.*; Leif, R. N.; Mulcahy, H. A.; Koester, C. “An alternate, highly efficient derivatization of pinacolyl alcohol for enhanced detection in gas chromatography-mass spectrometry using electron impact ionization” Anal. Bioanal. Chem. 406, 5231-5234 (2014) [DOI]

Floyd III, W. C.; Baker, S. E.; Valdez, C. A.; Stolaroff, J. K.; Bearinger, J. P.; Satcher Jr., J. H.; Aines, R. D.* “Evaluation of a carbonic anhydrase biomimetic for industrial carbon capture.” Environ. Sci. Technol. 47, 10049-10055 (2013) [DOI]

Kim, S. H.*; Shin, S. J.; Lenhardt, J. M.; Braun, T.; Sain, J. D.; Valdez, C. A.; Leif, R. N.; Kucheyev, S. O.; Wu, K. J. J.; Biener, J.; Satcher Jr., J. H.; Hamza, A. “Deterministic control over high-Z doping of polydicyclopentadiene-based aerogels and their coatings.” ACS Appl. Mater. Interfaces 5, 8111-8119 (2013) [DOI]

Lau, E. Y.; Wong, S. E.; Baker, S. E.; Bearinger, J. P.; Koziol, L.; Valdez, C. A.; Satcher, J. H.; Aines, R. D.*; Lightstone, F. C.* “Comparison and analysis of zinc and cobalt-based systems as catalytic entities for the hydration of carbon dioxide.” PLoS One 8, e66187 (2013) [DOI]

Koziol, L.; Essiz, S. G.; Wong, S. E.; Lau, E. Y.; Valdez, C. A.; Satcher, Jr. J. H.; Aines, R. D.*, Lightstone, F. C.* “Computational analysis of a Zn-bound tris(imidazolyl) calix[6]arene aqua complex: toward incorporating second coordination sphere effects into carbonic anhydrase biomimetics.” J. Chem. Theory Comput. 9, 1320-1327 (2013) [DOI]

Patents

Valdez, C. A.; Vu, A. K. “Methods for the selective detection of alkyne-presenting molecules and related compositions and systems” 9791463 (2017).

Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” 9453028 (2016).

Floyd III, W. C.; Valdez, C. A.; Aines, R. D.; Baker, S. E.; Satcher Jr., J. H. “Acyclic aza-containing ligands for use as catalytic carbon capture systems” 9259725 (2016).

Singh, R.; Li, H.; Zhao, H.; Kolluri, R.; Tso, K.; Ramphal, J.; Gu, S.; Valdez, C.; Zhang, J.; Stauffer, E.; Duncton, M.; Alvarez, S. “Protein kinase C inhibitors and uses thereof” 9149475 (2015).

Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” 9095593 (2015).

Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” 9040527 (2015).

Han, T. Y-j.; Valdez, C. A.; Olson, T. Y.; Kim, S. H.; Satcher Jr., J. H. “Rapid detection and identification of energetic materials with surface enhanced Raman spectroscopy (SERS)” 9012241 (2015).

Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.; Wong, S. E.; Baker, S. E.; Lightstone, F. C.; Stolaroff, J. K. “Tethered catalysts for the hydration of carbon dioxide” 8877069 (2014).

Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” 8519837 (2013).

Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.; Baker, S. E. “Synthesis of triazole-based and imidazole-based zinc catalysts” 8394351 (2013).

Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” 8394951 (2013).

Singh, R.; Li, H.; Zhao, H.; Kolluri, R.; Tso, K.; Ramphal, J.; Gu, S.; Valdez, C.; Zhang, J.; Stauffer, E.; Duncton, M.; Alvarez, S. “Protein kinase C inhibitors and uses thereof” 8377924 (2013) 

Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” 8278299 (2012).

Technical Reports

Singleton, M. J.; Valdez, C. A.; Hok, S.; Mulcahy, H. A. “Compound Specific Stable Isotope Signatures of Chemical Threat Agents: Incapacitants and Agents: Year 1 Final Report” 2016, LLNL-TR-704350.

Mayer, B. P.; Valdez, C. A.; DeHope, A. J.; Spackman, P. E.; Sanner, R. D.; Martinez, H. P.; Williams, A. M. “Multivariate Statistical Analysis of Orthogonal Mass Spectral Data for the Identification of Chemical Attribution Signatures of 3-Methylfentanyl” 2016, LLNL-TR-703546.

Mayer, B. P.; Corzett, T.; Corzett, M.; Valdez, C. A.; Harding, R.; Hok, S.; Kennedy, D. J.; Williams, A. M. “Towards the Application of Multinuclear NMR for the Detection of the Adduction of Cholinesterases by Sarin and the Kinetics of the Subsequent Aging Process” 2015, LLNL-TR-668860.

Williams, A. M.; Valdez, C. A.; Hok, S.; Udey, R. N.; Vu, A. K. “Synthesis of GB- and VX-Adducted Nonapeptides and HD-Adducted Tripeptides Indicative of Butyrylcholinesterase Exposure to GB and VX or Albumin Exposure to HD” 2013, LLNL-TR-646332.

Hok, S.; Udey, R.; Vu, A. K.; Valdez, C. A. “Expanded Pathway Signatures Analysis” DHS Chemical Forensics and Attribution Program, 2013.

Hok, S.; Valdez, C. A. “Pathway Signatures Analysis” DHS Chemical Forensics and Attribution Program, 2012.

Hok, S.; Valdez, C. A.; Koester, C. “Lewisite I Synthesis.” 2012, LLNL-TR-599032.

Williams, A. M.; Mulcahy, H. A.; Leif, R. N.; Valdez, C. A.; Vu, A. K. “Extraction and Detection of US VX and its Chemical Attribution Signatures in Food Matrices” 2012, LLNL-TR-598692.

Williams, A. M.; Mulcahy, H. A.; Leif, R. N.; Valdez, C. A.; Vu, A. K. “Preliminary Report on the Extraction and Detection of US VX and its Chemical Attribution Signatures in Bottled Water” 2012, LLNL-TR-584672. 

Martin, A. N.; Valdez, C. A.; Moulik, A.; Alcaraz, A. “Analysis of brodifacoum synthetic pathways for forensic applications” 2010, LLNL-TR-433953.

Hok, S.; Valdez, C. A. “Pathway Signatures Analysis” DHS Chemical Forensics and Attribution Program, 2010. 


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