Lawrence Livermore National Laboratory



Brian Mayer

Research Staff
Nuclear and Chemical Sciences Division


 +1 925-423-1128


DegreeDiscipline/InstitutionYear
Ph.D. Chemical Engineering
University of California at Berkeley
2009
B.S. Chemical Engineering
University of South Carolina, Columbia
2004

Research Interests

Chemical attribution of chemical warfare agents and acutely toxic chemicals; environmental remediation of toxic chemicals; development of medical countermeasures for nerve agents and opioids; environmental fate of acutely toxic chemicals; nuclear magnetic resonance (NMR); forensic analysis of “unknown unknowns”; hyphenated analytical techniques based in NMR; development of novel NMR methodologies for chemical forensics; analysis and characterization of biomarkers for toxic chemical exposure; cyclodextrins as scaffolds for countermeasure development; optimizing/characterization host-guest affinities through joint computational/analytical chemistries; solution-state complexation involving cyclodextrins and related host molecules; the interface between and synergies of computational and experimental NMR data.


Selected Recent Publications

Mayer, B. P.; DeHope, A. J.; Mew, D. A.; Spackman, P. E.; Williams, A. M. Chemical Attribution of Fentanyl Using Multivariate Statistical Analysis of Orthogonal Mass Spectral Data. Anal. Chem. 2016, 88, 4303-4310.

Mayer, B. P.; Kennedy, D. J.; Lau, E. Y.; Valdez, C. A. Solution-State Structure and Affinities of Cyclodextrin:Fentanyl Complexes by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation. J. Phys. Chem. B 2016, 120, 2423-2433.

Kennedy, D. J.; Mayer, B. P.; Baker, S.; Valdez, C. A. Kinetics and Speciation of Paraoxon Hydrolysis by Zinc(II)-Azamacrocycle Catalysts. Inorganica Chimica Acta 2015, 436, 123-131.

Valdez, C. A.; Leif, R. N.; Mayer, B. P. An Efficient, Optimized Synthesis of Fentanyl and Related Analogs. PLoS ONE 2014, 9, e108250.

Mayer, B. P.; Valdez, C. A.; Hok, S.; Chinn, S. C.; Hart, B. R. 31P-Edited Diffusion-Ordered 1H NMR Spectroscopy for the Spectral Isolation and Identification of Organophosphorus Compounds Related to Chemical Weapons Agents and Their Degradation Products. Anal. Chem. 2012, 84, 10478-10484.


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