Lawrence Livermore National Laboratory

Brian Mayer

Research Staff
Nuclear and Chemical Sciences Division

 +1 925-423-1128

Ph.D. Chemical Engineering
University of California at Berkeley
B.S. Chemical Engineering
University of South Carolina, Columbia

Research Interests

Chemical attribution of chemical warfare agents and acutely toxic chemicals; environmental remediation of toxic chemicals; development of medical countermeasures for nerve agents and opioids; environmental fate of acutely toxic chemicals; nuclear magnetic resonance (NMR); forensic analysis of “unknown unknowns”; hyphenated analytical techniques based in NMR; development of novel NMR methodologies for chemical forensics; analysis and characterization of biomarkers for toxic chemical exposure; cyclodextrins as scaffolds for countermeasure development; optimizing/characterization host-guest affinities through joint computational/analytical chemistries; solution-state complexation involving cyclodextrins and related host molecules; the interface between and synergies of computational and experimental NMR data.

Selected Recent Publications

Mayer, B. P.; DeHope, A. J.; Mew, D. A.; Spackman, P. E.; Williams, A. M. Chemical Attribution of Fentanyl Using Multivariate Statistical Analysis of Orthogonal Mass Spectral Data. Anal. Chem. 2016, 88, 4303-4310.

Mayer, B. P.; Kennedy, D. J.; Lau, E. Y.; Valdez, C. A. Solution-State Structure and Affinities of Cyclodextrin:Fentanyl Complexes by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation. J. Phys. Chem. B 2016, 120, 2423-2433.

Kennedy, D. J.; Mayer, B. P.; Baker, S.; Valdez, C. A. Kinetics and Speciation of Paraoxon Hydrolysis by Zinc(II)-Azamacrocycle Catalysts. Inorganica Chimica Acta 2015, 436, 123-131.

Valdez, C. A.; Leif, R. N.; Mayer, B. P. An Efficient, Optimized Synthesis of Fentanyl and Related Analogs. PLoS ONE 2014, 9, e108250.

Mayer, B. P.; Valdez, C. A.; Hok, S.; Chinn, S. C.; Hart, B. R. 31P-Edited Diffusion-Ordered 1H NMR Spectroscopy for the Spectral Isolation and Identification of Organophosphorus Compounds Related to Chemical Weapons Agents and Their Degradation Products. Anal. Chem. 2012, 84, 10478-10484.

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