Lawrence Livermore National Laboratory



Aleksandr Noy

Senior Scientist
Biosciences and Biotechnology Division


 +1 925-424-6203


DegreeDiscipline/InstitutionYear
Ph.D. Chemistry
Harvard University
1997
M.S. Chemistry
Harvard University
1995
B.A. Chemistry/Physics
Moscow State University
1992

Research Interests

Single-Molecule Biophysics, Intermolecular interactions in chemistry and biology; Chemical Force Microscopy; Scanning probe microscopy and its applications for measuring bio-logical forces; Applications of high-resolution imaging to biology.

Nanotechnology; Carbon nanotubes and molecular wires; Low-dimensional materials and their applications in single-molecule devices, Molecular self-assembly in systems with reduced dimensionality; Molecular transport in one-dimensional materials and structures.

Honors and Awards

  • LLNL Science and Technology Award (2001)
  • LLNL Lawrence Fellowship (05/1998-08/2001)
  • Fannie and John Hertz Foundation research grant (1995) Hertz Fellowship Finalist (1995)

Selected Publications

Artyukhin, A. B., A. Shestakov, J. Harper, O. Bakajin, P. Stroeve, and A. Noy, "Functional One-Dimensional Lipid Bilayerson Carbon Nanotube Templates," J. Am. Chem. Soc. (2005).

Vezenov, D. V., A. Noy, and P. D.Ashby, "Chemical Force Microscopy: Probing Chemical Origins of Interfacial Forces and Adhesion," J. Adh. Sci. Tech. (2005) (invited review).

Holt, J., A. Noy, T. Huser, D. Eaglesham, and O. Bakajin, "Fabrication of a Carbon Nanotube-Embedded Silicon Nitride Membrane for Studies of Nanometer-Scale Mass Transport," Nano Letters 4, 2245-2250 (2004).

Noy, A., "Direct Determination of the Equilibrium Unbinding Potential Profile for a Short DNA Duplex from Force Spectroscopy Data," Appl. Phys. Lett. 85 (20), 4792-4794 (2004).

Hau-Riege, S. P., H. Szoke, H. N. Chapman, A. Szoke, S. Marchesini, A. Noy, H. F. He, M. Howells, U. Weierstall, and J. C. H. Spence, "SPEDEN: Reconstructing Single Particles from Their Diffraction Patterns," Acta Crystallographica A60, (Part4), 294-305 (2004).

Friddle, R. W., J. E. Klare, S. S. Martin, M. Corzett, R. Balhorn, E. P. Baldwin, R. J. Baskin, and A. Noy, "Mechanism of DNA Compaction by Yeast Mitochondrial Protein Abf2p," Biophys. J. 86, 1632-1639 (2004).

Holt, J. K., H. G.Park, O. Bakajin, A. Noy, T. R. Huser, and D. Eaglesham, "Carbon Nanotube-Based Membranes: A Platform for Studying Nanofluidics," IEEE Nanotech Symp. Proc., Munich, Germany (2004).

Holt, J. K., H. Park, O. Bakajin, A. Noy, T. Huser, and D.Eaglesham, "Carbon Nanotube Based Permeable Membranes," Mat. Res. Soc. Symp. Proc. 820 (2004).

Artyukhin, A. B., O. Bakajin, P. Stroeve, and A. Noy, "Layer-by-Layer Electrostatic Self-Assembly of Polyelectrolyte Nanoshells on Individual Carbon Nanotube Templates," Langmuir 20, 1442-1448 (2003).

Brewer, L. R., R. W.Friddle, A. Noy, E. P. Baldwin, S. S.Martin, M. Corzette, R. Balhorn, and R. J. Baskin, "Packaging of Single DNA Molecules by the Yeast Mitochondrial Protein Abf2p," Biophys. J. 85, 2519-2524 (2003).

Bakajin, O., N. Ben-barak, J. Peng, and A. Noy, "Carbon Nanotube Based Microfluidic Elements for Filtration and Concentration," Micro Total Analysis Systems, Squaw Valley, CA, Transducers Research Foundation (2003).

Marchesini, S., H. He, H. Chapman, S. Hau-Riege, A. Noy, M. Howells, U. Weierstall, and J. C. H. Spence, "X-ray Imagere Construction from a Diffraction Pattern Alone," Phys. Rev. B. 68, 140101 (R) (2003).

He, H., S. Marchesini, M. Howells, U. Weierstall1, H. Chapman, S. Hau-Riege, A. Noy, and J. C. H. Spence, "Inversion of X-ray Diffuse Scattering to Images Using Prepared Objects," Phys. Rev.B. 67, 174114 (2003).

Vezenov, D. V., A. Noy, and C. M. Lieber, "Effect of Solvent Induced Adhesion Changes on the Interfacial Shear Strength between Self-Assembled Monolayers," J. Adhesion. Sci. Tech. 17, 1385-1401 (2003).

Zepeda, S., Y. Yeh, and A. Noy, "Determination of Energy Barriers for Intermolecular Interactions by Variable Temperature Dynamic Force Spectroscopy," Langmuir 19, 1457-1461 (2003); invited contribution.

Noy, A.,and T. R.Huser, "A Combined Force and Photonic Probe Microscope with Single Molecule Sensitivity," Rev. Sci. Instr. 74, 1217-1221 (2003).

Noy, A., S. Zepeda, C. A. Orme, Y. Yeh, and J. J. DeYoreo, "Entropic Barriers in Nanoscale Adhesion Studied by Variable Temperature Chemical Force Microscopy," J. Am. Chem. Soc. 125, 1356-1362 (2003).

Weeks, B. L., J. Camarero, A. Noy, A. E. Miller, L. Stanker, J. J. DeYoreo, "A Microcantilever-Based Pathogen Detector," Scanning 25, 297299 (2003).

Noy, A., A. E. Miller, J. E. Klare, B. Woods, B. L.Weeks, and J. J. DeYoreo, "Fabrication of Luminescent Nanostructures by Dip-Pen Nanolithography," SPIE Proceedings 4809, 249-254 (2002).

Weeks, B. L., A. Noy, A. E. Miller, and J. J. DeYoreo, "The Effect of Dissolution Kinetics on Feature Size in Dip-Pen Nanolithography," Phys. Rev. Lett. 8825, U85-U88 (2002).

Noy, A., A. E. Miller, J. E. Klare, B. Woods, B. L. Weeks, and J. J. DeYoreo, "Fabrication of Luminescent Nanostructures and Polymer Nanowires Using Dip-Pen Nanolithography," Nano Letters 2, 109-112 (2002).

Orme, C. A., A. Noy, A. Wierzbicki, M. T. McBride, M. Grantham, H. H. Teng, P. M. Dove, and J. J. DeYoreo, "Selective Binding of Amino Acids to the Atomic Steps of Calcite Creates Chiral Structures." Nature 411, 775-779 (2001).

Shestakov, A., J. Milovich, and A. Noy, "Using Pseudo-Transient Continuation and the Finite Elment Method to Solve the Nonlinear Poisson-Boltzmann Equation," J. Colloid. Interfac. Science 247, 62-79 (2002).

Noy, A., D. V. Vezenov, and C. M. Lieber, "Chemical Force Microscopy," Annual Reviews of Materials Science 27, 381-421 (1997).

Noy, A., D. V. Vezenov, J. F. Kayyem, T. J. Meade, and C. M. Lieber, "Stretching and Breaking Duplex DNA by Chemical Force Microscopy," Chemistry and Biology 4, 519-527 (1997).

Noy, A., C. H. Sanders, D. V. Vezenov, S. S. Wong, and C. M. Lieber, "Chemically Sensitive Imaging in Tapping Mode by Chemical Force Microscopy: Role of Tip-Sample Adhesive Interactions in Phase Lag Contrast," Langmuir 14, 1508-1511 (1998) cover article.

Noy, A., C. D. Frisbie, L. F. Rosznyai, M. S. Wrighton, and C. M. Lieber, "Chemical Force Microscopy: Exploiting Chemically Modified Tips to Quantify Adhesion, Frictionand Functional Group Distributions in Molecular Assemblies," J. Am. Chem. Soc. 117, p.7943-7951 (1995).

Vezenov, D. V., A. Noy, L. F. Rosznyai, and C. M. Lieber, "Force Titrations and Ionization State Sensitive Imaging of Functional Groups in Aqueous Solutions by Chemical Force Microscopy," J. Am. Chem. Soc. 119, 2006-2015 (1997).

Vezenov, D. V., A. Noy, and C. M. Lieber, "Chemical and Solvent Effects in Adhesion Probed by Chemical Force Microscopy," Proceedings of 20th Annual Meeting of Adhesion Society 23 (1997).

Frisbie, C. D., L. F. Rosznyai, A. Noy, M. S. Wrighton, and C. M. Lieber, "Functional Group Imaging by Chemical Force Microscopy,"

Books and Book Chapters

Editor, Handbook of Molecular Force Spectroscopy, published by Springer (2005).

Noy, A., Interactions at Solid-Liquid interfaces, in from Fluid-Solid Interfaces to Nano-structural Engineering," Eds. J. J. DeYoreo and X.-Y. Liu, Plenum/Kluwer Academic (2004).

Weeks, B. L., A. Noy, A. E. Miller, J. E. KLare, B. W. Woods, and J. J. DeYoreo, "Dip-Pen Nano-lithography Using MHA and Optical Inks," in Dekker Encyclopedia of Nanoscience and Nanotechnology, p.923-931, Marcel Dekker Publishers (2004).

Vezenov, D. V., A. Noy, and C. M. Lieber, "Probing and Imaging Interactions between Functional Groups Scanning Probe Microscopy in Polymers," ACS Symposium Series 694, ACS, Ch.19 (1998).


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