Lawrence Livermore National Laboratory




 +1 925-424-6266


DegreeDiscipline/InstitutionYear
Ph.D. Chemistry
University of California at Berkeley
1996
B.S. Chemistry
Rensselaer Polytechnic Institute
1987

Research Interests

My research is focused on developing instrumentation and techniques that directly impact people's lives, such as advancing accelerator mass spectrometry out of the nuclear physics laboratory and into the biomedical realm to address human health related issues.


Patents

  • Vogel JS, Ognibene TJ, Bench GS, Peaslee GF Reducing apparatus for quantitatively reducing oxide gases, comprises vial, and trapping mechanism for trapping oxide gases in vial (2009): US Patent No. US2004047766-A1; US7611903-B2
  • Turteltaub K, Ognibene T, Thomas A, Daley PF, Salazar Quintero GA, Bench G (2014) Interface for the Rapid Analysis of Liquid Samples by Accelerator Mass Spectrometry: US Patent No. US8642953-B2

Selected (Recent) Publications

Thomas AT, Stewart BJ, Ognibene TJ, Turteltaub KW, Bench G (2013). Directly Coupled High-Performance Liquid Chromatography-Accelerator Mass Spectrometry Measurement of Chemically Modified Protein and Peptides. Anal. Chem. 85(7): 3644-3650.
doi: 10.1021/ac303609n http://pubs.acs.org/doi/abs/10.1021/ac303609n

Salazar G, Ognibene T (2013). Design of a secondary ionization target for direct production of a C- beam from CO2 pulses for online AMS. Nucl. Instrum. Meth. B 294(0): 300-306.
doi: 10.1016/j.nimb.2012.03.039
http://www.sciencedirect.com/science/article/pii/S0168583X12003412

Ognibene TJ, Salazar GA (2013). Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer. Nucl. Instrum. Meth. B 294(0): 311-314.
doi: 10.1016/j.nimb.2011.11.029
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586325/

Stewart BJ, Bench G, Buchholz BA, Haack KW, Malfatti MA, Ognibene TJ, et al. (2012). Accelerator Mass Spectrometry in Pharmaceutical Development. In: Lee MS (ed). Mass Spectrometry Handbook, edn. Hoboken, New Jersey: John Wiley & Sons, Inc. pp 259-269. doi: 10.1002/9781118180730.ch12

Thomas AT, Ognibene T, Daley P, Turteltaub K, Radousky H, Bench G (2011). Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC). Anal. Chem. 83(24): 9413-9417.
doi: 10.1021/ac202013s http://www.ncbi.nlm.nih.gov/pubmed/22004428

Links J, Palmblad M, Ognibene T, Turteltaub K, Bench G (2010). Quantitative metabolism using AMS: Choosing a labeled precursor. Nucl. Instrum. Meth. B 268(7-8): 1309-1312.
doi: 10.1016/j.nimb.2009.10.160 http://www.ncbi.nlm.nih.gov/pubmed/20368758

Keck BD, Ognibene T, Vogel JS (2010). Analytical validation of accelerator mass spectrometry for pharmaceutical development. Bioanalysis 2(3): 469-485.
doi: 10.4155/bio.10.14 http://www.ncbi.nlm.nih.gov/pubmed/21083256

Sporty J, Lin SJ, Kato M, Ognibene T, Stewart B, Turteltaub K, et al. (2009). Quantitation of NAD(+) biosynthesis from the salvage pathway in Saccharomyces cerevisiae. Yeast 26(7): 363-369.
doi: 10.1002/yea.1671 http://onlinelibrary.wiley.com/doi/10.1002/yea.1671/full

Marsden DA, Jones DJL, Britton RG, Ognibene T, Ubick E, Johnson GE, et al. (2009). Dose-Response Relationships for N7-(2-Hydroxyethyl)Guanine Induced by Low-Dose [C-14]Ethylene Oxide: Evidence for a Novel Mechanism of Endogenous Adduct Formation. Cancer Research 69(7): 3052-3059.
doi: 10.1158/0008-5472.CAN-08-4233 http://www.ncbi.nlm.nih.gov/pubmed/19276345

Sporty JL, Kabir MM, Turteltaub KW, Ognibene T, Lin SJ, Bench G (2008). Single sample extraction protocol for the quantification of NAD and NADH redox states in Saccharomyces cerevisiae. Journal of Separation Science 31(18): 3202-3211.
doi: 10.1002/jssc.200800238 http://www.ncbi.nlm.nih.gov/pubmed/18763242

Coldwell KE, Cutts SM, Ognibene TJ, Henderson PT, Phillips DR (2008). Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations. Nucl. Acids Res. 36(16): e100-.
doi: 10.1093/nar/gkn439 http://www.ncbi.nlm.nih.gov/pubmed/18632763

Vogel JS, Palmblad NM, Ognibene T, Kabir MM, Buchholz BA, Bench G (2007). Biochemical paths in humans and cells: Frontiers of AMS bioanalysis. Nucl. Instrum. Meth. B 259(1): 745-751.
doi: 10.1016/j.nimb.2007.01.215 http://www.sciencedirect.com/science/article/pii/S0168583X07003266

Ognibene TJ, Bench G, Brown TA, Vogel JS (2007). Ion-optics calculations and preliminary precision estimates of the gas-capable ion source for the 1-MV LLNL BioAMS spectrometer. Nucl. Instrum. Meth. B 259(1): 100-105.
doi: 10.1016/j.nimb.2007.01.148 http://www.sciencedirect.com/science/article/pii/S0168583X07002121

Vogel JS, Ognibene T, Palmblad M, Reimer P (2004). Counting Statistics and Ion Interval Density in AMS. Radiocarbon 46(3): 1103-1109.


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